Oligonucleotide Synthesis Market Overview (2024–2030)

The Global Oligonucleotide Synthesis Market was valued at US$ 6.60 billion in 2023 and is projected to reach US$ 17.43 billion by 2030, growing at a strong CAGR of 14.87% during the forecast period. This rapid expansion is driven by rising demand for advanced genetic research tools, increasing adoption of personalized medicine, and growing applications in diagnostics and therapeutics.

Oligonucleotides are short DNA or RNA sequences synthesized using chemical and enzymatic techniques. They play a vital role in molecular biology, genetic engineering, drug discovery, and disease diagnosis. The increasing use of oligonucleotides in polymerase chain reaction (PCR), next-generation sequencing (NGS), gene therapy, and antisense therapies has significantly contributed to market growth. Additionally, advancements in automated DNA synthesizers and high-throughput technologies have enhanced production efficiency, further supporting market expansion.

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Market Dynamics

Key Growth Drivers

The primary driver of the oligonucleotide synthesis market is the rapid advancement in biotechnology and genomics research. The growing prevalence of chronic and genetic diseases has increased the need for targeted therapies, where oligonucleotides play a crucial role. Pharmaceutical and biotechnology companies are increasingly investing in RNA-based drugs, antisense therapies, and gene-editing technologies, driving sustained market demand.

Another major factor supporting growth is the expanding application of oligonucleotides in diagnostics. The rising adoption of molecular diagnostics, especially after the COVID-19 pandemic, has strengthened the demand for PCR and sequencing-based testing methods. Moreover, increasing government and private funding for life science research has further boosted market development.

Market Restraints

Despite strong growth prospects, the market faces certain challenges. Limited funding availability in academic research laboratories may restrict research activities, particularly in developing regions. In addition, the high cost of advanced synthesis equipment and raw materials can hinder market penetration among small research institutes.

The shortage of skilled professionals and the presence of a limited number of manufacturers in certain regions also pose barriers to market expansion. Regulatory complexities related to genetic research and therapeutic development may further impact growth in some markets.

Opportunities

Emerging markets in Asia Pacific and Latin America offer significant growth opportunities due to increasing healthcare investments and expanding biotechnology infrastructure. The rising focus on personalized medicine, RNA therapeutics, and CRISPR-based gene editing is expected to create new revenue streams for market players. Strategic collaborations, mergers, and acquisitions are also anticipated to accelerate technological innovation and market penetration.

Market Segmentation Analysis

By Product Type

The market is segmented into reagents & consumables, equipment, synthesized oligonucleotides, DNA oligonucleotides, RNA oligonucleotides, and others. Among these, the synthesized oligonucleotides segment dominated the market in 2023 and is expected to grow at the fastest rate. This dominance is attributed to their extensive usage in therapeutics, diagnostics, and research applications.

DNA and RNA oligonucleotides continue to gain traction due to their increasing role in vaccine development, gene therapy, and RNA-based treatments.

By Application

Based on application, the market is categorized into research, PCR, next-generation sequencing, therapeutics, diagnostics, and others. The therapeutics segment, including antisense oligonucleotides and nucleic acid aptamers, is witnessing rapid growth due to rising investments in targeted drug development.

PCR and sequencing applications also hold a significant market share, driven by growing demand for genetic testing, infectious disease detection, and cancer diagnostics.

By End User

The major end users include hospitals, pharmaceutical and biotechnology companies, diagnostic laboratories, CROs & CMOs, and academic research institutes. Among these, pharmaceutical and biotechnology companies lead the market due to their extensive use of oligonucleotides in drug discovery and clinical research.

Academic institutions and contract research organizations also contribute significantly, supported by increasing research collaborations and outsourcing activities.

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Regional Insights

North America

North America held the largest market share in 2023, driven by strong biotechnology infrastructure, high R&D spending, and the presence of major market players. The United States remains the dominant contributor due to its advanced healthcare system and favorable regulatory environment.

Asia Pacific

Asia Pacific is expected to register the highest CAGR during the forecast period. Countries such as China, Japan, and India are emerging as key growth hubs due to rising investments in genomics research, expanding pharmaceutical manufacturing, and supportive government initiatives.

Europe

Europe maintains steady growth, supported by strong academic research institutions and increasing adoption of molecular diagnostics. Germany, France, and the UK remain key contributors to regional revenue.

Middle East & Africa and South America

These regions are gradually witnessing market expansion due to improving healthcare infrastructure and rising awareness about genetic testing and personalized medicine.

Recent Developments

In March 2018, Danaher Corporation acquired Integrated DNA Technologies to strengthen its position in the genomics market and enhance diagnostic and therapeutic capabilities.

In February 2021, Integrated DNA Technologies acquired GeneWorks Pty Ltd. to expand its footprint in the Asia Pacific region and improve product accessibility for researchers worldwide.

Such strategic initiatives highlight the industry’s focus on geographical expansion and technological advancement.

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Competitive Landscape

The global oligonucleotide synthesis market is moderately consolidated, with key players focusing on innovation, capacity expansion, and strategic partnerships. Leading companies include Agilent Technologies, Thermo Fisher Scientific, Merck KGaA, Integrated DNA Technologies, Eurofins Genomics, Genscript, and Danaher Corporation.

Market participants are actively investing in advanced synthesis platforms, customized oligo services, and high-purity production processes to strengthen their competitive positioning.

Future Outlook

The Oligonucleotide Synthesis Market is expected to witness sustained growth through 2030, supported by rapid progress in genetic engineering, expanding therapeutic applications, and increasing adoption of personalized medicine. Technological innovations, combined with rising healthcare investments in emerging economies, will further accelerate market development.

As demand for precision medicine and molecular diagnostics continues to rise, oligonucleotide synthesis will remain a critical component of the global life sciences ecosystem.

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